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KMID : 0377220030280010039
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Medical Journal of Chosun Univercity
2003 Volume.28 No. 1 p.39 ~ p.49
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Immunohistochemical and electron microscopic study of inflammatory reaction in early and advanced gastric adenocarcinoma
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Kim Hwan-Jong
Lim Sung-Chul
Suh Chae-Hong
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Abstract
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Background and Object : Solid tumors progressively develop in parallel with a tumor stroma composed of new blood vessels, inflammatory cells and fibrosis Macrophages are a central component of this inflammatory reaction, and they can interact with the neoplastic as well as the stromal components of tumor tissue The "crophage balance’ hypothesis was introduced to depict the ambivalent relationship between tumor and macrophages Macrophages might influence neoplastic growth and progression in opposite direction, with a prevailing protumor activity in the absence of therapeutic intervention in many neoplasms. Macrophages, when appropriately activated, are able to eliminate neoplastic target cells in vitro The killing of tumor cells by macrophages requires cell-to-cell contact, but little is known about the mechanisms by which tumor infiltrating macrophages exert their postulated effects in vivo The authors investigated the tumor-infiltrating cells in early gastric carcinoma and advanced gastric carcinoma and described the ultrastructural features and interactions of macrophages with tumor cells and other inflammatory cells
Methods : Sections from 20 early gastric carcinomas and 56 advanced gastric carcinomas were stained by immunohistochemical methods for CD4, CD8, CD20, CD45 and CD68
Results : In all of the tumors, CD68-positive macrophages accounted for most tumor-infiltrating cells, followed by CD45-positive T lymphocytes, CD8-positive T lymphocytes &D4-positiveT lymphocytes in order of frequence The authors founded only a few CD20-positive B lymphocytes. Electron microscopy revealed macrophages with phagocytic vesicles and cellular debris The tumor cells in contact with macrophages showed no cymiddleathic changes Contacts among macrophages and other inflammatory cells formed a recurrent ultrastructural hallmark and suggest communication among various inflammatory cell types during the some host response to gastric carcinoma
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KEYWORD
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CD4, CD8, CD20, CD45, CD68, Stomach adenocarcinoma
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